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I, of course, go immediately to JRA
or Juvenile Rheumatiod Arthritis. Is there any swelling associated with it? Is it worse in the morning as soon as he wakes up? If either of these are a "yes" make your doctor rule out JRA. There are blood tests but they are inconclusive. X rays and bone scans don't work, at least not with us they didn't. We only got a definitive diagnosis with DD from an MRI.
You can go to the Arthritis Foundation's website for more info on it. My pediatric rheumatologist said that they're the only website who's information he trusts on the subject.
I found out about JRA by doing a google search with "limping toddler" as the key words. DD started limping at 20 months but wasn't diagnosed with JRA until much later.
We've found that Motrin doesn't work at all. We have prescription naproxen for DD when her ankle hurts.
Hope you find out what's causing it, soon.
______
"If you want your children to be bright, read them fairytales-- if you want them to be brilliant, read them even more fairytales" Albert Einstein