I have been on Remicade infusions for about 2 years not for Crohns but for Rheumatoid Arthritis. I get an infusion every 8 weeks and the results have been great. I haven't had any serious side effects and I have had no problems with the infusions. It is scary to go on a powerful drug. I too was very worried about it and I also have to be on Methotrexate along with the Remicade as this is how they use the drug for RA..in combination. though my Rheumatologist did say that they are now testing using the Remicade w/o the methotrexate. I am also on a low dose of prednisone;5mg a day and we want to try to cut that down since I am doing so well on the Remicade so here's hoping I can do that. Hope you do as well with Remicade for Crohns as I have for RA. Good Luck